Chlorpromazine vs Reserpine for Schizophrenia

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A controlled clinical study of chlorpromazine and reserpine in chronic schizophrenia.

Since their recent introduction into clinical practice, chlorpromazine and reserpine have been widely used in the treatment of the schizophrenias. Studies of schizophrenic patients treated with chlorpromazine have been published by Vaughan, Leiberman, and Cook (1955), Kinross-Wright (1955), Goldman (1955), Charatan (1954), Labhardt (1954) and Anton-Stephens (1954); treatment with reserpine has ...

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Chlorpromazine, reserpine, and isoniazid treatment in mental disorder; a preliminary communication.

We have to thank the Director of Medical Services, Kenya, for pennission to publish this paper and for the help and facilities he has given us in this work. We are grateful to Dr. D. M. Blomfield, Acting Provincial Medical Officer, Coast Province, for his help in the survey in his province. We are especially grateful to Dr. D. H. Mackay, Provincial Medical Officer, Nyanza, and to Dr. H. J. S. C...

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Effects of reserpine and chlorpromazine on 5-hydroxytryptamine uptake of platelets from migrainous and control subjects.

Platelet aggregation experiments confirm differences between the 5-hydroxytryptamine (5-HT) receptors of migrainous and control platelets. However, no differences have been found in 5-HT uptake, in the presence of reserpine or chlorpromazine, into migrainous and control platelets. The results support the hypothesis that receptors for 5-HT induced platelet aggregation provide a model for vascula...

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Clozapine v. chlorpromazine in treatment-naive first-episode schizophrenia.

BACKGROUND The differential effects of so-called 'first- and second generation' antipsychotic medications, when given in the first episode, on the long-term outcome of schizophrenia remain to be elucidated. AIMS We compared the 9-year outcomes of individuals initially randomised to clozapine or chlorpromazine. METHOD One-hundred and sixty individuals with treatment-naive, first episode schi...

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Olanzapine compared with chlorpromazine in treatment-resistant schizophrenia.

OBJECTIVE The purpose of this study was to compare the efficacy of olanzapine with that of chlorpromazine plus benztropine in patients with treatment-resistant schizophrenia. METHOD One hundred three previously treatment-resistant patients with schizophrenia diagnosed according to the DSM-III-R criteria were given a prospective 6-week trial of 10-40 mg/day of haloperidol. Eighty-four of them ...

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ژورنال

عنوان ژورنال: Schizophrenia Bulletin

سال: 2016

ISSN: 0586-7614,1745-1701

DOI: 10.1093/schbul/sbw016